Synthesis of gold nanorods

AIM :  Synthesis of gold nanorods using seed mediated method.

Publication referred : “Azide-Derivatized Gold Nanorods : Functional Materials for “Click” Chemistry.” Anand Gole and Catherin J Murphy (ACS 2008,24,266-72)

Abstract : Seed mediated gold nanorods synthesis is a two step procedure. Firstly, we need to synthesis gold seeds and then make growth solution.

PART 1 – Let us start by first learning how to make seed solution.

Materials and Equipment Required for Seed Solution:

Chemicals :

1. 0.6 ml, 10mM, NaBH4(Sodium borohydride; mol. wt. 37.83 da or g/mol; 1 dalton = 1 gram/mol)

2. 10 ml, 0.1 M, Gold Solution ( prepared from Gold (III) chloride trihydrate)

3. 10 ml, 0.1 M, CTAB solution ( Centrimonium bromide; mol. wt. 364.45 da)

4. Other equipment : 50 ml conical flask (1), magnetic stirrer, 10 ml standard flask (1), 25 ml beaker (1), crushed ice, magnetic bead, micro-pipette, lots of DI water. 

Procedure :

Step 1 : Wash all the utensils first with chromic acid followed by soap water, followed by DI water. Wash again by DI water. [this is the first and foremost step and very important too as we dont want any impurities because a dust particle of even 10nm radius can hinder the growth and create toxicity which we can not afford as these gold rods will be used in biological applications.]

Step 2 : Take 10 ml DI water in 50 ml conical flask. Now take CTAB; weigh it for 364.45 mg, and mix it with water in conical flask. Sonicate if it doesn’t disperse completely. Put the flask on stirrer with magnetic bead inside. [CTAB is a surfactant here.] 

Step 3 :  Take 3.7 mg NaBH4 in 10 ml DI water in 10 ml standard flask. [If small bubbles are observed then that’s the confirmation of NaBH4 dissolving in water.]

Step 4 : Now, pick 25 µl (microlitre) of gold solution from micro-pipette and pour it in the CTAB solution kept on stirrer. [the color of the solution should change to gold; if not, do over.]

Step 5 : Now, pick 600 µl of NaBh4 solution and add drop by drop to the golden colored (CTAB+Gold) solution kept on stirrer. [the color should become light brown after neutralizing golden color. Brown color confirms the formation of gold seeds.]

Step 6 : Stir for another 10 minutes and keep this beautiful seed solution aside for later use. 

Step 7 : Proceed to synthesis of growth solution by acquiring and  washing chemicals and equipment mentioned in the next part.

 

 

 

 

 

Targeted Drug Delivery : Overview of FDA approved nanoparticle platforms

I know its a boring job to read journal publishings which are so dull and boring and without nice pictures and animations but they are the ones carrying the keys to the better future. One such paper is “State-0f-the-art design rules for targeted drug delivery platforms: Lessons learned from FDA approved platforms.”

 

This paper was published in Journal of Controlled Release 187 (2014)  from page 133 to 144. Author of this paper is C.M.Dawidczyk and team.

[You can find the original paper here.]

To help you gain interest and to give you a better insight on the discussions of this paper, I have prepared a powerpoint presentation. I hope this presentation helps you understand in a simpler and better way and motivate you to take up the original paper and read it thoroughly to unlock the magical box of novel ideas hidden in you.

This is a review presentation and rights of its content (except images) are owned by the author and his team.

 

Design rules for targeted drug delivery and Lessons learned from FDA approved platforms

 

Please feel free to ask doubts/point out mistakes/help make future better.

Cheers to life!

Dont forget to vote, cz its your right.

single electron

“There is more than plenty of room at the bottom, maybe a bungalow “)